Publications: Research articles (with original data)

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• Maloney, G.E., Cloutier, M.E., Provost, M.J., Srivastava, L.K., Cermakian, N. (2025) Characterization of the expression and function of schizophrenia risk gene Dtnbp1 in the suprachiasmatic nucleus. Neuroscience, 595:250-260. https://doi.org/10.1016/j.neuroscience.2025.12.029
• Brown, T.W., Villalongue, N., Hales, S.C., Srikanta, S.B., Rochon, P.L., Rangel Olguin, A.G., Boy Waxman, S., Tufford, A., Van Prooijen, J., Krishnaswamy, A., Cermakian, N., Cayouette, M. (2025) Retinal glia regulate the development of the circadian photoentrainment circuit. Cell Reports, 44:116464. https://doi.org/10.1016/j.celrep.2025.116464
• Bouteldja, A.A., Marceau, L., Srivastava, L.K., Cermakian, N. (2025) Early life ventral hippocampal lesion and circadian disruption result in altered behavior in adult mice in a sex-dependent manner. European Journal of Neuroscience, 61:e70134. https://doi.org/10.1111/ejn.70134
• Delorme, T., Arcego, D.M., Penichet, D., O'Toole, N., Huebener, N., Silveira, P.P., Srivastava, L.K., Cermakian, N. (2025) Large-scale sex-specific interactions of prenatal immune activation and circadian disruption during adolescence at the behavioral, cellular and transcriptomic levels, with implications for neurodevelopmental disorders. Brain Behavior and Immunity, 127:409-422. https://doi.org/10.1016/j.bbi.2025.03.023
• Srikanta, S.B., Brown, T.W., Malescot, A., Cloutier, M.E., Zhu, L., Coutanson, C., Malki, M., Storch, K.F., Rungta, R., Cayouette, M., Dkhissi-Benyahya, O., Cermakian, N. (2025) The deubiquitinase USP2 modulates photic entrainment of the circadian clock at the level of the suprachiasmatic nucleus. Journal of Neurochemistry, 169:e70018. https://doi.org/10.1111/jnc.70018
• Carvalho Cabral, P., Richard, V.R., Borchers, C.H., Olivier, M., Cermakian, N. (2024) Circadian Control of the Response of Macrophages to Plasmodium spp.-Infected Red Blood Cells. ImmunoHorizons, 8(6):442–456. https://doi.org/10.4049/immunohorizons.2400021
• Carvalho Cabral, P., Stegeman, S.K., Olivier, M., Cermakian, N. (2024) Circadian regulation of Leishmania parasite internalization in macrophages and downstream cellular events. Parasite Immunology, 46: e13053. https://doi.org/10.1111/pim.13053
• • Balit, N., Cermakian, N., Khadra, A. (2024) The influence of circadian rhythms on CD8+ T cell activation upon vaccination: a mathematical modeling perspective. Journal of Theoretical Biology, 590, 111852. https://doi.org/10.1016/j.jtbi.2024.111852
• • Carvalho Cabral, P., Weinerman, J., Olivier, M., Cermakian, N. (2024) Time of day and circadian disruption influence host response and parasite growth in a mouse model of cerebral malaria. iScience, 27:109684. https://doi.org/10.1016/j.isci.2024.109684
• Walker, C.D., Delorme, T.C., Kiessling, S., Long, H, Cermakian, N. (2023) Peripheral clock gene oscillations are perturbed in neonatal and adult rat offspring raised under adverse limited bedding conditions. Scientific Reports, 13:22886.
• Delorme, T.C., Ozell-Landry, W., Cermakian, N.#, Srivastava, L.K.# (2023) Behavioral and cellular responses to circadian disruption and prenatal immune activation in mice. Scientific Reports, 13:7791.  # Co-corresponding authors
• Kervezee, L., Koshy, A., Cermakian, N.#, Boivin, D.B.# (2023) The effect of night shifts on 24-h rhythms in the urinary metabolome of police officers on a rotating work schedule. Journal of Biological Rhythms, 38(1):64-76. doi: 10.1177/07487304221132088.  # Co-corresponding authors
• Cloutier, M.E., Srivastava, L.K., Cermakian, N. (2022) Exposure to circadian disruption during adolescence interacts with Dtnbp1 gene to modify schizophrenia-relevant behaviors in a sex-dependant manner. Journal of Biological Rhythms, 37(6): 655-672.  doi: 10.1177/07487304221125363.
• Delorme, T.C., Srikanta S.B., Fisk, A.S., Cloutier, M.E., Sato, M., Pothecary, C.A., Merz, C., Foster, R.G., Brown, S.A., Peirson, S.N., Cermakian, N.#, Banks, G.T.# (2022) Chronic exposure to dim light at night or irregular lighting conditions impact circadian behavior, motor coordination, and neuronal morphology. Frontiers in Neuroscience, 16:855154. doi: 10.3389/fnins.2022.855154. # Co-corresponding authors
• Bouchard., A., Dsouza, C., Julien, C., Rummler, M., Gaumond, M.-H., Cermakian, N. , Willie, B.M. (2022) Bone adaptation to mechanical loading in mice is affected by circadian rhythms, Bone, 154:116218.  doi: 10.1016/j.bone.2021.116218.
• Srikanta, S.B., Stojkovic, K., Cermakian, N. (2021) Behavioral phenotyping of mice lacking the deubiquitinase USP2. PLOS ONE, 23;16(2):e0241403.
• Delorme, T.C., Srivastava, L.K., Cermakian, N. (2021) Altered Circadian Rhythms in a Mouse Model of Neurodevelopmental Disorders Based on Prenatal Maternal Immune Activation. Brain Behavior and Immunity, 93:119-131.
• Nobis, C.C., Dubeau-Laramée, G., Kervezee, L., Maurice-De Sousa, D., Labrecque, N.#, Cermakian, N.# (2019) The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways. Proc Natl Acad Sci USA, 1;116(40):20077-20086. # Co-corresponding author
• Kervezee, L., Cermakian, N.#, Boivin, D.B.# (2019) Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans. PLOS Biology, 18;17(6):e3000303.  # Co-corresponding author
• Koshy, A., Cuesta, M., Boudreau, P., Cermakian, N.#, Boivin, D.B.# (2019) Disruption of central and peripheral circadian clocks in police officers working at night. FASEB Journal, 33(6):6789-6800.  # Co-corresponding authors
• Kervezee, L., Cuesta, M., Cermakian, N.#, Boivin, D.B.# (2019) The phase-shifting effect of bright light exposure on circadian rhythmicity in the human transcriptome. Journal of Biological Rhythms, 34(1):84-97.  # Co-corresponding authors
• Kervezee, L., Cuesta, M., Cermakian, N.#, Boivin, D.B.# (2018) Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome. Proc Natl Acad Sci USA, 115(21):5540-5545.  # Co-corresponding authors
• Hannou, L., Bélanger-Nelson, E., O’Callaghan, E.K., Dufort-Gervais, J., Ballester Roig, M.N., Roy, P.G., Beaulieu, J.M., Cermakian, N., Mongrain, V. (2018) Regulation of the Neuroligin-1 Gene by Clock Transcription Factors. Journal of Biological Rhythms, 33(2):166-178.
• Kiessling, S., O'Callaghan, E.K., Freyburger, M., Cermakian, N., Mongrain, V. (2018) The cell adhesion molecule EphA4 is involved in circadian clock function and light response in the suprachiasmatic nucleus. Genes Brain and Behavior, 17(1):82-92.
• Cuesta, M., Boudreau, P., Cermakian, N.#, Boivin, D.B.# (2017) Rapid resetting of human peripheral clocks by phototherapy during simulated night shift work. Scientific Reports, 7:16310.  # Co-corresponding authors
• Kiessling, S., Dubeau-Laramée, G., Ohm, H., Labrecque, N., Olivier, M., Cermakian, N. (2017) The circadian clock in immune cells controls the magnitude of Leishmania parasite infection. Scientific Reports, 7:10892.
• Uetani, N., Hardy, S., Gravel, S.P., Kiessling, S., Pietrobon, A., Wong, N.N., Chénard, V., Cermakian, N., St-Pierre, J., Tremblay, M.L. (2017) PRL-2 links magnesium flux and sex-dependent circadian metabolic rhythms. JCI Insight, 2(13):e91722.
• Cuesta, M., Boudreau, P., Cermakian, N., Boivin, D.B. (2017) Skin temperature rhythms in humans respond to changes in the timing of sleep and light. Journal of Biological Rhythms, 32(3):257-273.
• Kiessling, S., Beaulieu-Laroche, L., Blum, I., Landgraf, D., Welsh, D.K., Storch, K.F., Labrecque, N., Cermakian, N. (2017) Enhancing circadian clock function in cancer cells inhibits tumor growth. BMC Biology, 15:13.
• Cuesta, M., Boudreau, P., Dubeau-Laramée, G., Cermakian, N.#, Boivin, D.B.# (2016) Simulated night shift disrupts circadian rhythms of immune functions in humans. Journal of Immunology, 196(6):2466-75.  # Co-corresponding authors
• Freyburger, M., Pierre, A., Paquette, G., Bélanger-Nelson, E., Bedont, J., Gaudreault, P.O., Drolet, G., Laforest, S., Blackshaw, S., Cermakian, N., Doucet, G., Mongrain, V. (2016) EphA4 is involved in sleep regulation but not in the electrophysiological response to sleep deprivation. Sleep, 39(3):613-24.
• Landgraf, D., Joiner, W.J., McCarthy, M.J., Kiessling, S., Barandas, R., Young, J.W., Cermakian, N., Welsh, D.K. (2016) The mood stabilizer valproic acid opposes the effects of dopamine on circadian rhythms. Neuropharmacology, 107:262-270.
• Bhardwaj, S.K., Stojkovic, K., Kiessling, S., Srivastava, L.K., Cermakian, N. (2015) Constant light uncovers behavioral effects of a mutation in the schizophrenia risk gene Dtnbp1 in mice. Behavioural Brain Research, 284:58-68.
• Cuesta, M., Cermakian, N., Boivin, D.B. (2015) Glucocorticoids entrain molecular clock components in human peripheral cells. FASEB Journal, 29(4):1360-70.
• Reynolds, L.M., Makowski, C.S., Yogendran, S.V., Kiessling, S., Cermakian, N., Flores, C. (2015) Amphetamine in adolescence disrupts the development of medial prefrontal cortex dopamine connectivity in a dcc-dependent manner. Neuropsychopharmacology, 40:1101-12.
• Yang, Y., Duguay, D., Fahrenkrug, J., Cermakian, N., Wing, S.S. (2014) USP2 regulates the intracellular localization of PER1 and circadian gene expression. Journal of Biological Rhythms, 29(4):243-256. 
• Westfall, S., Aguilar-Valles, A., Mongrain, V., Luheshi, G.N., Cermakian, N. (2013) Time-dependent effects of localized inflammation on peripheral clock gene expression in rats. PLoS ONE, 8(3): e59808.
• Yang, Y., Duguay, D., Bédard, N., Rachalski, A., Baquiran, G., Na, C.H., Fahrenkrug, J., Storch, K.F., Peng, J., Wing, S.S., Cermakian, N. (2012) Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2. Biology Open, 1:789-801.
• Fortier, E.E., Rooney, J., Dardente, H., Hardy, M.P., Labrecque, N., Cermakian, N. (2011) Circadian variation of the response of T cells to antigen. Journal of Immunology, 187(12):6291-300.
• Duguay, D., Bélanger-Nelson, E., Mongrain, V., Beben, A., Khatchadourian, A., Cermakian, N. (2011) Dynein light chain Tctex-type 1 modulates orexin signaling through its interaction with orexin 1 receptor. PLoS ONE, 6(10): e26430.
• Dufour, C.R., Pham, N.H.H., Levasseur, M.P., Eichner, L.J., Wilson, B.J., Duguay, D., Poirier-Héon, J.F., Cermakian, N., Giguère, V. (2011) Genomic convergence between ERR, PROX1 and BMAL1 in circadian control of metabolism. PLoS Genetics, 7(6):e1002143.
• Cermakian, N., Waddington Lamont, E., Boudreau, P., Boivin, D.B. (2011) Circadian clock gene expression in brain regions of Alzheimer's disease patients and control subjects. Journal of Biological Rhythms, 26(2):160-170.
• Rousseau, J., Klinger, S., Rachalski, A., Turgeon, B., Déléris, P., Vigneault, E., Poirier-Héon, J.F., Davoli, M.A., Mechawar, N., El Mestikawy, S., Cermakian, N., Meloche, S. (2010) Targeted Inactivation of Mapk4 in Mice Reveals Specific Non-Redundant Functions of Erk3/Erk4 Subfamily MAP Kinases. Mol Cell Biol, 30(24):5752-63.
• Labialle, S., Croteau, S., Bélanger, V., McMurray, E.N., Ruan, X.,, Moussette, S., Jonnaert, M., Schmidt, J.V., Cermakian, N., Naumova, A.K. (2008) Novel imprinted transcripts from the Dlk1-Gtl2 intergenic region, Mico1 and Mico1os, show circadian oscillations. Epigenetics, 3(6):322-9.
• Mongrain, V., Ruan, X., Dardente, H., Fortier, E.E., Cermakian, N. (2008) Clock-dependent and independent transcriptional control of the two isoforms from the mouse Ror gene. Genes to Cells, 13(12):1197-1210.
• Labialle, S., Yang, L., Ruan, X., Villemain, A., Schmidt, J.V., Hernandez, A., Wiltshire, T., Cermakian, N., Naumova, A.K. (2008) Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Human Molecular Genetics, 17(1):15-26.
• James, F.O., Boivin, D.B., Charbonneau, S., Bélanger, V., Cermakian, N. (2007) Expression of clock genes in human peripheral blood mononuclear cells throughout the sleep/wake and circadian cycles. Chronobiology International, 24(6):1009-1034.
• James, F.O., Cermakian, N., Boivin, D.B. (2007) Circadian rhythms of melatonin, cortisol and clock gene expression to during simulated night shift work. Sleep, 30(11):1427-1436.
• Dardente, H., Fortier, E.E., Martineau, V., Cermakian, N. (2007) CRYPTOCHROMES impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repression. Biochemical Journal, 402(3):525-536.
• Doi, M., Cho, S., Yujnovsky, I., Hirayama, J., Cermakian, N., Cato, A.C.B., Sassone-Corsi, P. (2007) Light-inducible and clock-controlled expression of MAP Kinase Phosphatase 1 in the mouse central pacemaker neurons. Journal of Biological Rhythms, 22(2):127-139.
• Bélanger, V., Picard, N., Cermakian, N. (2006) The circadian regulation of Presenilin-2 gene expression. Chronobiology International, 23(4):747-766.
• Guillaumond, F., Dardente, H., Giguère, V., Cermakian, N. (2005) Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptors. Journal of Biological Rhythms, 20(5):391-403.
• • Granda, T., Liu, X.H., Cermakian, N., Smaaland, R., Filipski, E., Sassone-Corsi, P., Lévi, F. (2004) Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumour. FASEB Journal 19(2):304-306.
• Morse, D.*, Cermakian, N.*, Brancorsini, S., Parvinen, M., Sassone-Corsi, P. (2003) No circadian rhythm in testis: Period1 expression is Clock independent and developmentally regulated in the mouse. Molecular Endocrinology 17(1):141-151.* Co-first authors
• Pando, M.P., Morse, D., Cermakian, N., Sassone-Corsi, P. (2002) Phenotypic rescue of a peripheral clock genetic defect via SCN hierarchical dominance. Cell 110(1):107-117.
• Travnickova-Bendova, Z., Cermakian, N., Reppert, S.M., Sassone-Corsi, P. (2002) Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK:BMAL1 activity. Proc Natl Acad Sci USA 99(11):7728-7733.
• Cermakian, N.*, Pando, M.P.*, Thompson, C.L.*, Pinchak, A.B., Selby, C.P., Gutierrez, L., Wells, D.E., Cahill, G.M., Sancar, A., Sassone-Corsi, P. (2002) Light induction of a vertebrate clock gene involves signaling through blue-light receptors and MAP kinases. Current Biology 12(10):844-848. * Co-first authors
• Cermakian, N., Monaco, L., Pando, M.P., Dierich, A., Sassone-Corsi, P. (2001) Altered behavioral rhythms and clock gene expression in mice with a targeted mutation in the Period1 gene. The EMBO Journal 20:3967-3974.
• Pando, M.P., Pinchak, A.B., Cermakian, N., Sassone-Corsi, P. (2001) A cell based system that recapitulates the dynamic light-dependent regulation of the vertebrate clock. Proc Natl Acad Sci USA 98(18):10178-10183.
• Li, J., Maga, J.A., Cermakian, N., Cedergren, R., Feagin, J.E. (2001) Identification and characterization of a Plasmodium falciparum RNA polymerase gene with similarity to mitochondrial RNA polymerases. Molecular and Biochemical Parasitology 113:261-269.
• Crosio, C.*, Cermakian, N.*, Allis, C.D., Sassone-Corsi, P. (2000) Light induces chromatin modification in cells of the mammalian circadian clock. Nature Neuroscience 3(12): 1241-1247. * Co-first authors
• Cermakian, N., Whitmore, D., Foulkes, N.S., Sassone-Corsi, P. (2000) Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function. Proc Natl Acad Sci USA 97(8):4339-4344.
• Cermakian, N., McClain, W.H., Cedergren, R. (1998) tRNA nucleotide 47: an evolutionary enigma. RNA 4(8):928-936.
• Bourdeau, V., Steinberg, S.V., Ferbeyre, G., Emond, R., Cermakian, N., Cedergren, R. (1998) Amber suppression in Escherichia coli by unusual mitochondria-like transfer RNAs. Proc Natl Acad Sci USA 95(4):1375-1380.
• Cermakian, N.*, Ikeda, T.M.*, Miramontes, P., Lang, B.F., Gray, M.W., Cedergren, R. (1997) On the evolution of the single-subunit RNA polymerases. Journal of Molecular Evolution 45(6):671-681. * Co-first authors
• Cermakian, N., Ikeda, T.M., Cedergren, R., Gray, M.W. (1996) Sequences homologous to yeast mitochondrial and bacteriophage T3 and T7 RNA polymerase genes are widespread throughout the eukaryotic lineage. Nucleic Acid Research 24(4):648-654.

This content has been updated on 15 January 2026 at 15h42.